Bone: A rigid body tissue that makes up our body’s skeleton.
Craft: Skill and experience

BoneCraft.nl describes the expertise and experience of the Bone, Imaging & Genomics (BIG) research group of the Department of Internal Medicine at Erasmus MC. Our group is committed to transforming BIG research discoveries into tangible clinical solutions for individuals vulnerable to (musculo)skeletal disorders and other complex diseases.

Lines of research

The research of the BIG group is organized along four lines, with the first three defining the team organization (on expertise and trajectory); while the fourth line represents the clinical translation arm of the BIG group, implementing discoveries generated by the other research lines in the form of health benefit for the general population and improved patient care.

Bone Biology & Mechanistic Research

Our research aims at elucidating the cellular, molecular, and physiological mechanisms underlying the regulation of bone development, remodelling, adaptation, repair and disease.

Image: Backscatter SEM of Trabecular Bone by bone resorbing osteoclasts

Population Musculoskeletal Genomics, Imaging and Life-Course Epidemiology

We aim at identifying genetic, molecular, environmental, and lifestyle determinants of musculoskeletal traits and diseases throughout life using population-based cohorts and high-throughput genomic and imaging technologies.

Rare and Atypical Skeletal Disorders

Our research aims at improving the understanding, diagnosis, and management of rare skeletal diseases and atypical presentations of common (musculo)skeletal disorders.

mage: Mikael Häggström, M.D., CC0.

Clinical Phenomics and Precision Skeletal Medicine

We integrate clinical phenotyping, imaging, genomics, and molecular profiling to transform how we diagnose, predict, and treat musculoskeletal diseases. By applying machine learning to population and patient big data, we bridge biology, genetics, environment, and lifestyle—paving the way for advanced fracture risk prediction, targeted prevention, and personalized health outcomes.

Projects

FIDELIO, funded by Horizon 2020, trained researchers on bone fragility in type 2 diabetes, focusing on genetic mechanisms and biomarkers for improved detection and treatment

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Featured Staff

Veerle Lubbers

Research assistant

Mijn naam is Veerle Lubbers, ik ben in februari 2023 afgestudeerd als arts en heb daarna een jaar in het HMC Westeinde in Den Haag gewerkt op de afdelingen Spoed Eisende Hulp en Neurologie. In de tussentijd heb ik mij bezig gehouden met onderzoek, waarvan ik op de International Conference on Emergency Medicine 2023 mijn resultaten mocht presenteren.

Mijn Favoriete sport is Hockey.