Deliverable 2

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Deliverable 1

Lorem ipsum Lorem ipsum dolor sit amet, consectetur adipiscing elit. Praesent ullamcorper faucibus convallis. Pellentesque non odio purus. Donec ut lectus eget orci convallis lacinia eget ac risus. Nunc maximus in lorem ullamcorper pharetra. Maecenas nulla sem, dapibus et diam at, faucibus ultricies purus. Nullam tempor massa id enim pharetra, et accumsan elit consequat. Curabitur […]

WP5

Work package 5 Translating Genomic and Imaging Insights into Clinical Practice for Improved Bone Health All work packages Integrated genomic profiling and Imaging clustering of patients (clinical setting): The objective of this work package is to translate genomic discoveries and imaging insights on skeletal fragility into clinical practice, with the aim of improving patient care. […]

WP4

Work package 4 Revolutionizing Bone Disease Diagnosis with AI-Deep Learning Artificial intelligence-deep learning: The objective of this work package is to employ artificial intelligence-deep learning (AI-DL) approaches to revolutionize current clinical approaches to bone disease. In recent years, artificial intelligence, particularly deep learning (DL) and convolutional neural networks (CNN), has made significant strides in the […]

WP3

Work package 3 Enhancing Bone Quality Assessment: Integrating RPI Technology in Skeletal Research Large-scale assessment of bone quality (Osteoprobe): The objective of this work package is to advance beyond traditional bone mineral density (BMD) measurements and assess bone quality as a determinant of bone fragility and fracture risk, as well as the potential detrimental effects […]

WP2

EOS Edge system participant Birgit Doorn i

Work package 2 Revolutionizing Skeletal Research with Large-Scale EOS 3D X-Ray Imaging Large-scale EOS 3D X-ray imaging: The objective of this work package is to establish a comprehensive collection of innovative skeletal imaging assessments to advance research on skeletal fragility. To accomplish this, we will acquire an EOS® medical imaging system to perform whole-body scans […]

Work Packages

LEGENDARE is a European Research Council (ERC) funded research project aimed at advancing our understanding of human skeletal fragility and associated conditions through innovative genomic approaches. The project is structured into five distinct work packages (WP’s), each focusing on a different area of expertise to comprehensively address the challenges of bone health and fragility.

WP1

Work package 1 Refining Genomic Profiles for Improved Insights into Skeletal Diseases Integrated genomic profiling and Imaging clustering of patients (clinical setting): The objective of this work package is to translate genomic discoveries and imaging insights on skeletal fragility into clinical practice, with the aim of improving patient care. Genomic studies provide a wealth of […]

Legendare HOME

LEGENDARE is a program funded by the ERC Advanced Grant No.20800 500 aimed at using genomics for preventing and managing human skeletal fragility and associated conditions.