Maria Carolina Medina Gomez

Assistant professor

Studied Chemical Engineering and Microbiology, and holds a master in Biostatistics. She obtained her PhD in 2016, entitled “Disentangling the Heterogeneity of Bone Accrual”, investigating the interplay between genetics and body composition in the determination of peak bone mass. In total, she has 9 years of research experience after her PhD and 6 years of experience as supervisor, with two graduated PhD students of which 1 received a laurate (cum laude) degree.

Favorite

“My favorite writer is Jorge Luis Borges”

Currently supervises 4 PhD students and is also actively involved in teaching, coordinating two postgraduate courses in genomics and microbiome research. She has been selected member of the ECTS Academy, a prestigious “rising star” leadership program of the European Calcified Tissue Society. She co-authors 145 scientific papers (h-index 48) of which many in high impact journals (e.g. Nature, Nature Communications, Nature Genetics, American Journal of Human Genetics. Her work is at the forefront of cutting-edge methods in (statistical) genomics, transcriptomics and proteomics. Since 2016, she extended her research to microbiome research integrating genetic, genomic and gut microbiome data. Having received diverse research society awards, she is frequently invited to lecture at diverse international research settings.

1.Bone health index in the assessment of bone health: The Generation R Study

Prijatelj, V., Grgic, O., Uitterlinden, A. G., Wolvius, E. B., Rivadeneira, F. & Medina-Gomez, C, May 2024, In: Bone. 182, 117070.

2. Early-life stress and the gut microbiome: A comprehensive population-based investigation

Mulder, R. H., Kraaij, R., Schuurmans, I. K., Frances-Cuesta, C., Sanz, Y., Medina-Gomez, C, Duijts, L., Rivadeneira, F., Tiemeier, H., Jaddoe, V. W. V., Felix, J. F. & Cecil, C. A. M., May 2024, In: Brain, Behavior, and Immunity. 118, p. 117-127 11 p.

3.Oral microbiota of adolescents with dental caries: A systematic review

Veenman, F., van Dijk, A., Arredondo, A., Medina-Gomez, C, Wolvius, E., Rivadeneira, F., Àlvarez, G., Blanc, V. & Kragt, L., Apr 2024, In: Archives of Oral Biology. 161, 105933.

4. Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Ghatan, S., van Rooij, J., van Hoek, M., Boer, C. G., Felix, J. F., Kavousi, M., Jaddoe, V. W., Sijbrands, E. J. G., Medina-Gomez, C, Rivadeneira, F. & Oei, L., 10 Jan 2024, (E-pub ahead of print) In: Genome Medicine. 16, 1, 10.

5.Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review

Li, R., Shokri, F., Rincon, A. L., Rivadeneira, F., Medina-Gomez, C & Ahmadizar, F., 1 Aug 2023, In: Genes. 14, 8, 1572.

6.Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Medina-Gomez, C, Mullin, B. H., Chesi, A., Prijatelj, V., Kemp, J. P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T. E., Schraut, K. E., Li-Gao, R., Ahluwalia, T. S., Zillikens, M. C., Zhu, K., Mook-Kanamori, D. O., Evans, D. S., Nethander, M., Knol, M. J., Thorleifsson, G., & 38 others, 4 Jul 2023, In: Communications Biology. 6, 1, 691.

7.Advanced Glycation End Products (AGEs) in Diet and Skin in Relation to Stool Microbiota: The Rotterdam Study

Chen, J., Radjabzadeh, D., Medina-Gomez, C, Voortman, T., van Meurs, J. B. J., Ikram, M. A., Uitterlinden, A. G., Kraaij, R. & Zillikens, M. C., Jun 2023, In: Nutrients. 15, 11, 2567.

8.Association of Bone Mineral Density and Dementia: The Rotterdam Study

Xiao, T., Ghatan, S., Mooldijk, S. S., Trajanoska, K., Oei, L., Gomez, M. M., Ikram, M. K., Rivadeneira, F. & Ikram, M. A., 16 May 2023, In: Neurology. 100, 20, p. e2125-e2133

9. Novel Genetic Determinants of Dental Maturation in Children

Grgic, O., Prijatelj, V., Dudakovic, A., Vucic, S., Dhamo, B., Trajanoska, K., Monnereau, C., Zrimsek, M., Gautvik, K. M., Reppe, S., Shimizu, E., Timpson, N. J., Jaddoe, V. W. V., Jarvelin, M. R., Evans, D., Uitterlinden, A. G., Ongkosuwito, E. M., van Wijnen, A. J., Medina-Gomez, C, Rivadeneira, F., & 1 others, Mar 2023, In: Journal of Dental Research. 102, 3, p. 349-356 8 p.

10.The gut microbiome and child mental health: A population-based study

Kraaij, R., Schuurmans, I. K., Radjabzadeh, D., Tiemeier, H., Dinan, T. G., Uitterlinden, A. G., Hillegers, M., Jaddoe, V. W. V., Duijts, L., Moll, H., Rivadeneira, F., Medina-Gomez, C, Jansen, P. W. & Cecil, C. A. M., Feb 2023, In: Brain, Behavior, and Immunity. 108, p. 188-196 9 p.

11.Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants

Young, K. L., Fisher, V., Deng, X., Brody, J. A., Graff, M., Lim, E., Lin, B. M., Xu, H., Amin, N., An, P., Aslibekyan, S., Fohner, A. E., Hidalgo, B., Lenzini, P., Kraaij, R., Medina-Gomez, C, Prokić, I., Rivadeneira, F., Sitlani, C., Tao, R., & 42 others, 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100163.

12. The genetic overlap between osteoporosis and craniosynostosis

Kague, E., Medina-Gomez, C, Boyadjiev, S. A. & Rivadeneira, F., 26 Sept 2022, In: Frontiers in Endocrinology. 13, 1020821.

13.Genetic Evidence for a Causal Role of Serum Phosphate in Coronary Artery Calcification: The Rotterdam Study

Campos-Obando, N., Bosman, A., Kavousi, M., Medina-Gomez, C, van der Eerden, B. C. J., Bos, D., Franco, O. H., Uitterlinden, A. G. & Zillikens, M. C., 2 Aug 2022, In: Journal of the American Heart Association. 11, 15, e023024.

14. Serum Phosphate, BMI, and Body Composition of Middle-Aged and Older Adults: A Cross-Sectional Association Analysis and Bidirectional Mendelian Randomization Study

Bosman, A., Campos-Obando, N., Medina-Gomez, C, Voortman, T., Uitterlinden, A. G. & Zillikens, M. C., 1 Jan 2022, In: Journal of Nutrition. 152, 1, p. 276-285 10 p.

15.CYP11B1 variants influence skeletal maturation via alternative splicing

Grgic, O., Gazzara, M. R., Chesi, A., Medina-Gomez, C, Cousminer, D. L., Mitchell, J. A., Prijatelj, V., de Vries, J., Shevroja, E., McCormack, S. E., Kalkwarf, H. J., Lappe, J. M., Gilsanz, V., Oberfield, S. E., Shepherd, J. A., Kelly, A., Mahboubi, S., Faucz, F. R., Feelders, R. A., de Jong, F. H., & 10 others, 9 Nov 2021, In: Communications Biology. 4, 1, 1274.

16. A comparison of genotyping arrays

Verlouw, J. A. M., Clemens, E., de Vries, J. H., Zolk, O., Verkerk, A. J. M. H., am Zehnhoff-Dinnesen, A., Medina-Gomez, C, Lanvers-Kaminsky, C., Rivadeneira, F., Langer, T., van Meurs, J. B. J., van den Heuvel-Eibrink, M. M., Uitterlinden, A. G. & Broer, L., Nov 2021, In: European Journal of Human Genetics. 29, 11, p. 1611-1624 14 p.

17. The Polygenic and Monogenic Basis of Paediatric Fractures

Ghatan, S., Costantini, A., Li, R., De Bruin, C., Appelman-Dijkstra, N. M., Winter, E. M., Oei, L. & Medina-Gomez, C, Oct 2021, In: Current Osteoporosis Reports. 19, 5, p. 481-493 13 p.

18. The Gut Microbiome: a New Frontier in Musculoskeletal Research

Li, R., Boer, C. G., Oei, L. & Medina-Gomez, C, Jun 2021, In: Current Osteoporosis Reports. 19, 3, p. 347-357 11 p.

19. An ARHGAP25 variant links aberrant Rac1 function to early-onset skeletal fragility

Mäkitie, R. E., Henning, P., Jiu, Y., Kämpe, A., Kogan, K., Costantini, A., Välimäki, V. V., Medina-Gomez, C, Pekkinen, M., Salusky, I. B., Schalin-Jäntti, C., Haanpää, M. K., Rivadeneira, F., Bassett, J. H. D., Williams, G. R., Lerner, U. H., Pereira, R. C., Lappalainen, P. & Mäkitie, O., 6 May 2021, In: JBMR Plus. 5, 7, e10509.

20. A population-based study on associations of stool microbiota with atopic diseases in school-age children

Hu, C., van Meel, E. R., Medina-Gomez, C, Kraaij, R., Barroso, M., Kiefte-de Jong, J., Radjabzadeh, D., Pasmans, S. G. M. A., de Jong, N. W., de Jongste, J. C., Moll, H. A., Nijsten, T., Rivadeneira, F., Pardo, L. M. & Duijts, L., 13 Apr 2021, In: Journal of Allergy and Clinical Immunology. 148, 2, p. 612-620 9 p.

21. Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population-Based Study of 1,355 Adults

Alferink, L., Radjabzadeh, D., Erler, N., Vojinovic, D., Medina Gomez, M., Uitterlinden, A., de Knegt, R., Amin, N., Ikram, A., Janssen, HL., Jong, J., Metselaar, H., Duijn, C., Kraaij, R. & Darwish Murad, S., Mar 2021, In: Hepatology. 73, 3, p. 968-982 15 p.

22. Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov, A., Medina Gomez, M., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, CI., Garay, JAR., Finnicum, CT., Liu, XR., Zhernakova, DV., Bonder, MJ., Hansen, TH., Frost, F., Ruhlemann, MC., Turpin, W., Moon, JY., Kim, HN., Lull, K., Barkan, E., & 84 others, Feb 2021, In: Nature Genetics. 53, 2, p. 156-165 10 p.

23. Genome-wide association study identifies 48 common genetic variants associated with handedness

Cuellar-Partida, G., Tung, JY., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, OA., Barroso, I., Beckmann, JS., Boks, M. P., Boomsma, DI., Boyd, HA., Breteler, M., Campbell, H., Chasman, DI., Cherkas, LF., Davies, G., de Geus, EJCN., Deary, IJ., Deloukas, P., Dick, DM., & 98 others, Jan 2021, In: Nature Human Behaviour. 5, 1, p. 59-70 12 p.

24. Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non–Weight-Bearing Human Bone

Gautvik, KM., Günther, CC., Prijatelj, V., Medina Gomez, M., Shevroja, E., Rad, LH., Yazdani, M., Lindalen, E., Valland, H., Gautvik, VT., Olstad, OK., Holden, M., Rivadeneira, F., Utheim, TP. & Reppe, S., 2020, In: Journal of Bone and Mineral Research. 35, 6, p. 1065-1076 12 p.

25. Diversity, compositional and functional differences between gut microbiota of children and adults

Radjabzadeh, D., Boer, C., Beth, S., van der Wal, P., Jong, J., Jansen, M., Konstantinov, S., Peppelenbosch, M., Hays, J., Jaddoe, V., Ikram, A., Rivadeneira, F., van Meurs, J., Uitterlinden, A., Medina Gomez, M., Moll, H. & Kraaij, R., 2020, In: Scientific Reports. 10

26. Genetic basis of falling risk susceptibility in the UK Biobank Study

Trajanoska, K., Seppala, LJ., Medina Gomez, M., Hsu, YH., Zhou, SR., Schoor, NM., de Groot, LCPCM., Karasik, D., Richards, JB., Kiel, DP., Uitterlinden, A., Perry, J., van de Velde, N., Day, F. & Rivadeneira, F., 2020, In: Communications Biology. 3, 1, 543.

27. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang, S., Bradfield, JP., Ahluwalia, TS., Curtin, JA., Lakka, TA., Grarup, N., Monnereau, C., Medina Gomez, M., Rivadeneira, F., Uitterlinden, A., Grant, SFA., Jaddoe, V. & Felix, J., 2020, In: PLoS Genetics (online). 16, 10, e1008718.

28. Skeletal maturation in relation to ethnic background in children of school age: The Generation R Study

Grgic, O., Shevroja, E., Dhamo, B., Uitterlinden, A., Wolvius, E., Rivadeneira, F. & Medina Gomez, M., 2020, In: Bone. 132, Unsp 115180.

29. An atlas of genetic influences on osteoporosis in humans and mice

Morris, JA., Kemp, JP., Youlten, SE., Laurent, L., Logan, JG., Chai, RC., Medina Gomez, M., Trajanoska, K., Evans, DM. & Richards, JB., 2019, In: Nature Genetics. 51, 2, p. 258-266 9 p.

30. Associations of autozygosity with a broad range of human phenotypes

Clark, DW., Okada, Y., Moore, KHS., Mason, D., Pirastu, N., Gandin, I., Medina Gomez, M., Felix, J., Jaddoe, V., Rietveld, N., Kubo, M. & Wilson, JF., 2019, In: Nature Communications. 10, 4957.

31. Disentangling the genetics of lean mass

Karasik, D., Zillikens, M. C., Hsu, YH., Aghdassi, A., Akesson, K., Amin, N., Broer, L., Campos Obando, N., Enneman, A., Estrada Gil, K., Hofman, B., Kloth, J., Medina Gomez, M., Oostra, B., Rivadeneira, F., Stolk, L., Uitterlinden, A., Duijn, C., Kiel, DP. & Ohlsson, C., 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287 12 p.

32. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Spracklen, CN., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, RS., Kutalik, Z., Amin, N., Broer, L., Demirkan, A., Duijn, C., Ikram, A., Medina Gomez, M., Prokic, I., Uitterlinden, A., Loos, RJF. & Mohlke, KL., 2019, In: American Journal of Human Genetics. 105, 1, p. 15-28 14 p.

  1. Femoral stress is prominently associated with fracture risk in children: The Generation R Study

Olja Grgic, Fernando Rivadeneira, Enisa Shevroja, Katerina Trajanoska, Vincent W V Jaddoe, Andre G Uitterlinden, Thomas J Beck, Eppo B Wolvius, Carolina Medina-Gomez. 2019.. Bone. 122:150-155.

  1. Fractures in school age children in relation to sex and ethnic background: The Generation R Study. Bone

Olja Grgic, Kuan Chung, Enisa Shevroja, Katerina Trajanoska, Andre G Uitterlinden, Eppo B Wolvius, Fernando Rivadeneira, Carolina Medina-Gomez. 2019.. 121:227-231.

 

  1. Journal of Bone Mineral Research

 Carolina Medina-Gomez, Denise H M Heppe, Jia-Lian Yin, Katerina Trajanoska, André G Uitterlinden, Thomas J Beck, Vincent W V Jaddoe, Fernando Rivadeneira. 2016.  31(5):1099-106.

2004

Best Thesis project written second semester.

2005

Chemical engineering Department –  Universidad de los Andes

2010-2011

Best Master of Science manuscript written under the supervision – NIHES tutor Epidemiology Department ErasmusMC

2011

New Investigator Award – American Society of Bone and Mineral Research

2012

Travel Grant Plenary Poster – American Society of Bone and Mineral Research.

New Investigator Award – European Calcified Tissue Society

2013

New Investigator Award  – 6th International Conference of Children’s Bone Health

2014-2016

Best PhD Thesis Award –  Dutch Bone and Mineral Society NVCB

2015

New Investigator Award – 7th International Conference of Children’s Bone Health

Semifinalist for the 2015 Charles J. Epstein Trainee Award for Excellence in Human Genetics Research – 65th annual meeting of the American Society of Human Genetics

2016

ECTS Travel award – European Calcified Tissue Society

2017

Travel award ICCBH  – ICCBH 2017- Salzburg

2019

ECTS Travel award – European Calcified Tissue Society