Maria Carolina Medina Gomez
Studied Chemical Engineering and Microbiology, and holds a master in Biostatistics. She obtained her PhD in 2016, entitled “Disentangling the Heterogeneity of Bone Accrual”, investigating the interplay between genetics and body composition in the determination of peak bone mass. In total, she has 9 years of research experience after her PhD and 6 years of experience as supervisor, with two graduated PhD students of which 1 received a laurate (cum laude) degree.
Favorite
“My favorite writer is Jorge Luis Borges”
Currently supervises 4 PhD students and is also actively involved in teaching, coordinating two postgraduate courses in genomics and microbiome research. She has been selected member of the ECTS Academy, a prestigious “rising star” leadership program of the European Calcified Tissue Society. She co-authors 145 scientific papers (h-index 48) of which many in high impact journals (e.g. Nature, Nature Communications, Nature Genetics, American Journal of Human Genetics. Her work is at the forefront of cutting-edge methods in (statistical) genomics, transcriptomics and proteomics. Since 2016, she extended her research to microbiome research integrating genetic, genomic and gut microbiome data. Having received diverse research society awards, she is frequently invited to lecture at diverse international research settings.
- Projects
- Publications
- Awards
1.Bone health index in the assessment of bone health: The Generation R Study
Prijatelj, V., Grgic, O., Uitterlinden, A. G., Wolvius, E. B., Rivadeneira, F. & Medina-Gomez, C, May 2024, In: Bone. 182, 117070.
2. Early-life stress and the gut microbiome: A comprehensive population-based investigation
Mulder, R. H., Kraaij, R., Schuurmans, I. K., Frances-Cuesta, C., Sanz, Y., Medina-Gomez, C, Duijts, L., Rivadeneira, F., Tiemeier, H., Jaddoe, V. W. V., Felix, J. F. & Cecil, C. A. M., May 2024, In: Brain, Behavior, and Immunity. 118, p. 117-127 11 p.
3.Oral microbiota of adolescents with dental caries: A systematic review
Veenman, F., van Dijk, A., Arredondo, A., Medina-Gomez, C, Wolvius, E., Rivadeneira, F., Àlvarez, G., Blanc, V. & Kragt, L., Apr 2024, In: Archives of Oral Biology. 161, 105933.
Ghatan, S., van Rooij, J., van Hoek, M., Boer, C. G., Felix, J. F., Kavousi, M., Jaddoe, V. W., Sijbrands, E. J. G., Medina-Gomez, C, Rivadeneira, F. & Oei, L., 10 Jan 2024, (E-pub ahead of print) In: Genome Medicine. 16, 1, 10.
Li, R., Shokri, F., Rincon, A. L., Rivadeneira, F., Medina-Gomez, C & Ahmadizar, F., 1 Aug 2023, In: Genes. 14, 8, 1572.
Medina-Gomez, C, Mullin, B. H., Chesi, A., Prijatelj, V., Kemp, J. P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T. E., Schraut, K. E., Li-Gao, R., Ahluwalia, T. S., Zillikens, M. C., Zhu, K., Mook-Kanamori, D. O., Evans, D. S., Nethander, M., Knol, M. J., Thorleifsson, G., & 38 others, 4 Jul 2023, In: Communications Biology. 6, 1, 691.
Chen, J., Radjabzadeh, D., Medina-Gomez, C, Voortman, T., van Meurs, J. B. J., Ikram, M. A., Uitterlinden, A. G., Kraaij, R. & Zillikens, M. C., Jun 2023, In: Nutrients. 15, 11, 2567.
8.Association of Bone Mineral Density and Dementia: The Rotterdam Study
Xiao, T., Ghatan, S., Mooldijk, S. S., Trajanoska, K., Oei, L., Gomez, M. M., Ikram, M. K., Rivadeneira, F. & Ikram, M. A., 16 May 2023, In: Neurology. 100, 20, p. e2125-e2133
9. Novel Genetic Determinants of Dental Maturation in Children
Grgic, O., Prijatelj, V., Dudakovic, A., Vucic, S., Dhamo, B., Trajanoska, K., Monnereau, C., Zrimsek, M., Gautvik, K. M., Reppe, S., Shimizu, E., Timpson, N. J., Jaddoe, V. W. V., Jarvelin, M. R., Evans, D., Uitterlinden, A. G., Ongkosuwito, E. M., van Wijnen, A. J., Medina-Gomez, C, Rivadeneira, F., & 1 others, Mar 2023, In: Journal of Dental Research. 102, 3, p. 349-356 8 p.
10.The gut microbiome and child mental health: A population-based study
Kraaij, R., Schuurmans, I. K., Radjabzadeh, D., Tiemeier, H., Dinan, T. G., Uitterlinden, A. G., Hillegers, M., Jaddoe, V. W. V., Duijts, L., Moll, H., Rivadeneira, F., Medina-Gomez, C, Jansen, P. W. & Cecil, C. A. M., Feb 2023, In: Brain, Behavior, and Immunity. 108, p. 188-196 9 p.
Young, K. L., Fisher, V., Deng, X., Brody, J. A., Graff, M., Lim, E., Lin, B. M., Xu, H., Amin, N., An, P., Aslibekyan, S., Fohner, A. E., Hidalgo, B., Lenzini, P., Kraaij, R., Medina-Gomez, C, Prokić, I., Rivadeneira, F., Sitlani, C., Tao, R., & 42 others, 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100163.
12. The genetic overlap between osteoporosis and craniosynostosis
Kague, E., Medina-Gomez, C, Boyadjiev, S. A. & Rivadeneira, F., 26 Sept 2022, In: Frontiers in Endocrinology. 13, 1020821.
Campos-Obando, N., Bosman, A., Kavousi, M., Medina-Gomez, C, van der Eerden, B. C. J., Bos, D., Franco, O. H., Uitterlinden, A. G. & Zillikens, M. C., 2 Aug 2022, In: Journal of the American Heart Association. 11, 15, e023024.
Bosman, A., Campos-Obando, N., Medina-Gomez, C, Voortman, T., Uitterlinden, A. G. & Zillikens, M. C., 1 Jan 2022, In: Journal of Nutrition. 152, 1, p. 276-285 10 p.
15.CYP11B1 variants influence skeletal maturation via alternative splicing
Grgic, O., Gazzara, M. R., Chesi, A., Medina-Gomez, C, Cousminer, D. L., Mitchell, J. A., Prijatelj, V., de Vries, J., Shevroja, E., McCormack, S. E., Kalkwarf, H. J., Lappe, J. M., Gilsanz, V., Oberfield, S. E., Shepherd, J. A., Kelly, A., Mahboubi, S., Faucz, F. R., Feelders, R. A., de Jong, F. H., & 10 others, 9 Nov 2021, In: Communications Biology. 4, 1, 1274.
16. A comparison of genotyping arrays
Verlouw, J. A. M., Clemens, E., de Vries, J. H., Zolk, O., Verkerk, A. J. M. H., am Zehnhoff-Dinnesen, A., Medina-Gomez, C, Lanvers-Kaminsky, C., Rivadeneira, F., Langer, T., van Meurs, J. B. J., van den Heuvel-Eibrink, M. M., Uitterlinden, A. G. & Broer, L., Nov 2021, In: European Journal of Human Genetics. 29, 11, p. 1611-1624 14 p.
17. The Polygenic and Monogenic Basis of Paediatric Fractures
Ghatan, S., Costantini, A., Li, R., De Bruin, C., Appelman-Dijkstra, N. M., Winter, E. M., Oei, L. & Medina-Gomez, C, Oct 2021, In: Current Osteoporosis Reports. 19, 5, p. 481-493 13 p.
18. The Gut Microbiome: a New Frontier in Musculoskeletal Research
Li, R., Boer, C. G., Oei, L. & Medina-Gomez, C, Jun 2021, In: Current Osteoporosis Reports. 19, 3, p. 347-357 11 p.
19. An ARHGAP25 variant links aberrant Rac1 function to early-onset skeletal fragility
Mäkitie, R. E., Henning, P., Jiu, Y., Kämpe, A., Kogan, K., Costantini, A., Välimäki, V. V., Medina-Gomez, C, Pekkinen, M., Salusky, I. B., Schalin-Jäntti, C., Haanpää, M. K., Rivadeneira, F., Bassett, J. H. D., Williams, G. R., Lerner, U. H., Pereira, R. C., Lappalainen, P. & Mäkitie, O., 6 May 2021, In: JBMR Plus. 5, 7, e10509.
Hu, C., van Meel, E. R., Medina-Gomez, C, Kraaij, R., Barroso, M., Kiefte-de Jong, J., Radjabzadeh, D., Pasmans, S. G. M. A., de Jong, N. W., de Jongste, J. C., Moll, H. A., Nijsten, T., Rivadeneira, F., Pardo, L. M. & Duijts, L., 13 Apr 2021, In: Journal of Allergy and Clinical Immunology. 148, 2, p. 612-620 9 p.
Alferink, L., Radjabzadeh, D., Erler, N., Vojinovic, D., Medina Gomez, M., Uitterlinden, A., de Knegt, R., Amin, N., Ikram, A., Janssen, HL., Jong, J., Metselaar, H., Duijn, C., Kraaij, R. & Darwish Murad, S., Mar 2021, In: Hepatology. 73, 3, p. 968-982 15 p.
22. Large-scale association analyses identify host factors influencing human gut microbiome composition
Kurilshikov, A., Medina Gomez, M., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, CI., Garay, JAR., Finnicum, CT., Liu, XR., Zhernakova, DV., Bonder, MJ., Hansen, TH., Frost, F., Ruhlemann, MC., Turpin, W., Moon, JY., Kim, HN., Lull, K., Barkan, E., & 84 others, Feb 2021, In: Nature Genetics. 53, 2, p. 156-165 10 p.
23. Genome-wide association study identifies 48 common genetic variants associated with handedness
Cuellar-Partida, G., Tung, JY., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, OA., Barroso, I., Beckmann, JS., Boks, M. P., Boomsma, DI., Boyd, HA., Breteler, M., Campbell, H., Chasman, DI., Cherkas, LF., Davies, G., de Geus, EJCN., Deary, IJ., Deloukas, P., Dick, DM., & 98 others, Jan 2021, In: Nature Human Behaviour. 5, 1, p. 59-70 12 p.
Gautvik, KM., Günther, CC., Prijatelj, V., Medina Gomez, M., Shevroja, E., Rad, LH., Yazdani, M., Lindalen, E., Valland, H., Gautvik, VT., Olstad, OK., Holden, M., Rivadeneira, F., Utheim, TP. & Reppe, S., 2020, In: Journal of Bone and Mineral Research. 35, 6, p. 1065-1076 12 p.
25. Diversity, compositional and functional differences between gut microbiota of children and adults
Radjabzadeh, D., Boer, C., Beth, S., van der Wal, P., Jong, J., Jansen, M., Konstantinov, S., Peppelenbosch, M., Hays, J., Jaddoe, V., Ikram, A., Rivadeneira, F., van Meurs, J., Uitterlinden, A., Medina Gomez, M., Moll, H. & Kraaij, R., 2020, In: Scientific Reports. 10
26. Genetic basis of falling risk susceptibility in the UK Biobank Study
Trajanoska, K., Seppala, LJ., Medina Gomez, M., Hsu, YH., Zhou, SR., Schoor, NM., de Groot, LCPCM., Karasik, D., Richards, JB., Kiel, DP., Uitterlinden, A., Perry, J., van de Velde, N., Day, F. & Rivadeneira, F., 2020, In: Communications Biology. 3, 1, 543.
27. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Vogelezang, S., Bradfield, JP., Ahluwalia, TS., Curtin, JA., Lakka, TA., Grarup, N., Monnereau, C., Medina Gomez, M., Rivadeneira, F., Uitterlinden, A., Grant, SFA., Jaddoe, V. & Felix, J., 2020, In: PLoS Genetics (online). 16, 10, e1008718.
Grgic, O., Shevroja, E., Dhamo, B., Uitterlinden, A., Wolvius, E., Rivadeneira, F. & Medina Gomez, M., 2020, In: Bone. 132, Unsp 115180.
29. An atlas of genetic influences on osteoporosis in humans and mice
Morris, JA., Kemp, JP., Youlten, SE., Laurent, L., Logan, JG., Chai, RC., Medina Gomez, M., Trajanoska, K., Evans, DM. & Richards, JB., 2019, In: Nature Genetics. 51, 2, p. 258-266 9 p.
30. Associations of autozygosity with a broad range of human phenotypes
Clark, DW., Okada, Y., Moore, KHS., Mason, D., Pirastu, N., Gandin, I., Medina Gomez, M., Felix, J., Jaddoe, V., Rietveld, N., Kubo, M. & Wilson, JF., 2019, In: Nature Communications. 10, 4957.
31. Disentangling the genetics of lean mass
Karasik, D., Zillikens, M. C., Hsu, YH., Aghdassi, A., Akesson, K., Amin, N., Broer, L., Campos Obando, N., Enneman, A., Estrada Gil, K., Hofman, B., Kloth, J., Medina Gomez, M., Oostra, B., Rivadeneira, F., Stolk, L., Uitterlinden, A., Duijn, C., Kiel, DP. & Ohlsson, C., 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287 12 p.
32. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology
Spracklen, CN., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, RS., Kutalik, Z., Amin, N., Broer, L., Demirkan, A., Duijn, C., Ikram, A., Medina Gomez, M., Prokic, I., Uitterlinden, A., Loos, RJF. & Mohlke, KL., 2019, In: American Journal of Human Genetics. 105, 1, p. 15-28 14 p.
Femoral stress is prominently associated with fracture risk in children: The Generation R Study
Olja Grgic, Fernando Rivadeneira, Enisa Shevroja, Katerina Trajanoska, Vincent W V Jaddoe, Andre G Uitterlinden, Thomas J Beck, Eppo B Wolvius, Carolina Medina-Gomez. 2019.. Bone. 122:150-155.
Fractures in school age children in relation to sex and ethnic background: The Generation R Study. Bone
Olja Grgic, Kuan Chung, Enisa Shevroja, Katerina Trajanoska, Andre G Uitterlinden, Eppo B Wolvius, Fernando Rivadeneira, Carolina Medina-Gomez. 2019.. 121:227-231.
Journal of Bone Mineral Research
Carolina Medina-Gomez, Denise H M Heppe, Jia-Lian Yin, Katerina Trajanoska, André G Uitterlinden, Thomas J Beck, Vincent W V Jaddoe, Fernando Rivadeneira. 2016. 31(5):1099-106.
2004
Best Thesis project written second semester.
2005
Chemical engineering Department – Universidad de los Andes
2010-2011
Best Master of Science manuscript written under the supervision – NIHES tutor Epidemiology Department ErasmusMC
2011
New Investigator Award – American Society of Bone and Mineral Research
2012
Travel Grant Plenary Poster – American Society of Bone and Mineral Research.
New Investigator Award – European Calcified Tissue Society
2013
New Investigator Award – 6th International Conference of Children’s Bone Health
2014-2016
Best PhD Thesis Award – Dutch Bone and Mineral Society NVCB
2015
New Investigator Award – 7th International Conference of Children’s Bone Health
Semifinalist for the 2015 Charles J. Epstein Trainee Award for Excellence in Human Genetics Research – 65th annual meeting of the American Society of Human Genetics
2016
ECTS Travel award – European Calcified Tissue Society
2017
Travel award ICCBH – ICCBH 2017- Salzburg
2019
ECTS Travel award – European Calcified Tissue Society