LEGENDARE is an innovative research program funded by the European Research Council (ERC) Advanced Grant No. 20800 500, with the primary objective of leveraging genomics to better understand, prevent, and manage human skeletal fragility and its related conditions. This program focuses on advancing our knowledge of the genetic underpinnings of bone health and fragility, aiming to identify key genetic factors that contribute to skeletal disorders such as osteoporosis, fractures, and other bone-related diseases.

By harnessing the power of cutting-edge genomic technologies, LEGENDARE seeks to create personalized, targeted approaches to improving bone health, providing insights into early diagnosis, risk prediction, and the development of more effective therapeutic strategies. The program also emphasizes the development of advanced tools for assessing individual susceptibility to bone fragility and offers a promising pathway for designing tailored treatments, enhancing patient care, and ultimately improving quality of life for those affected by these conditions.

In addition to its focus on skeletal fragility, LEGENDARE also aims to foster international collaborations and multidisciplinary research, bringing together geneticists, clinicians, bioinformaticians, and other specialists to create a comprehensive approach to bone health that extends beyond treatment to encompass prevention, management, and even potential cures. This ambitious initiative stands at the forefront of transforming how we approach bone diseases and their impact on individuals and societies globally.