LEGENDARE, funded by the European Research Council (ERC) Advanced Grant No. 101021500, is a pioneering research program focused on understanding, preventing, and managing skeletal fragility and related conditions. By exploring the genetic causes of bone diseases like osteoporosis and fractures, LEGENDARE aims to develop personalized approaches for early diagnosis, risk prediction, and more effective treatments.

The program fosters international collaboration, bringing together experts from diverse fields to create a holistic strategy for bone health, focusing on prevention, management, and potential cures. LEGENDARE is at the forefront of transforming bone disease research and improving patient outcomes globally.

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Scientists Information

Work package 1

Refining Genomic Profiles for Improved Insights into Skeletal Diseases

Optimization of genomic profiles: The goal of this work package is to refine genome profiling methods in order to gain new molecular and clinical insights into the phenotypic characteristics of skeletal diseases, such as osteoporosis and fragility fractures.
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EOS Edge system participant Birgit Doorn i

Work package 2

Revolutionizing Skeletal Research with Large-Scale EOS 3D X-Ray Imaging

Large-scale EOS 3D X-ray imaging: The objective of this work package is to establish a comprehensive collection of innovative skeletal imaging assessments to advance research on skeletal fragility.
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Work package 3

Enhancing Bone Quality Assessment: Integrating RPI Technology in Skeletal Research

Large-scale assessment of bone quality (Osteoprobe): The objective of this work package is to advance beyond traditional bone mineral density (BMD) measurements and assess bone quality as a determinant of bone fragility and fracture risk, as well as the potential detrimental effects of disease states on skeletal health.
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Work package 4

Revolutionizing Bone Disease Diagnosis with AI-Deep Learning

Artificial intelligence-deep learning: The objective of this work package is to employ artificial intelligence-deep learning (AI-DL) approaches to revolutionize current clinical approaches to bone disease.
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Work package 5

Translating Genomic and Imaging Insights into Clinical Practice for Improved Bone Health

Integrated genomic profiling and Imaging clustering of patients (clinical setting): The objective of this work package is to translate genomic discoveries and imaging insights on skeletal fragility into clinical practice, with the aim of improving patient care.
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Team members

Fernando Rivadeneira

Professor Dr. M.D PhD.

Katerina Trajanoska

Assistant professor

Fjorda Koromani

PhD Researcher

Kirsty Huininga

PhD Researcher

Ethel de Jong

Research assistant

Veerle Lubbers

Research assistant

Siwen LI

PhD Researcher

Partners

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