How do your genes and lifestyle work together to shape your bone health? The SINTER Study is here to find out!

SINTER is an observational Recall-by-Genotype (RbG) study focused on skeletal fragility in individuals with chronic diseases. By combining genetic information (polygenic risk scores for bone mineral density) with in-depth musculoskeletal phenotyping, the study aims to uncover the biological and lifestyle factors contributing to bone fragility.

🧪 Stage 1: Blood samples and genetic profiling from 5,650 adults across eight Erasmus MC outpatient clinics:
Botcentrum, Diabetology, Center for Healthy Weight, Nephrology, Vascular Medicine, Thyroid Center, Geriatrics, and Mastocytosis.

🦴 Stage 2: From this group, 1,500 participants with genetically high or low bone density will be invited back for deep phenotyping. This includes DXA scans, full-body EOS imaging, bone and muscle strength testing, and lifestyle assessments.

Recruitment has already started in the Mastocytosis clinic, with other departments preparing to follow.

Ethical approval?✅ Secured!
The study is funded by the prestigious LEGENDARE Advanced Grant (No. 101021500), awarded to Prof. Fernando Rivadeneira.

For more information, visit our website: sinteronderzoek.nl