Research setting
The research axes outlined in the lines of research are developed by forming a research group within the Genetic Laboratory of the Department of Internal Medicine. In this capacity, we will provide advisory support for activities conducted by the Human Genomics Facility, particularly focusing on analytical aspects related to microarray and sequencing data. Additionally, we aim to foster research interactions and collaborations with other research groups both within and outside the Endocrinology sector, as well as within and outside of the department. These connections will extend the scope of skeletal research to other bodily systems, with the skeletal setting serving as a model of translational genomics for other fields. A key component of the Translational Skeletal Genomics program is our close collaboration with the Erasmus MC Bone Center, where the majority of efforts to integrate genetics into a clinical setting will be concentrated.
The research axes outlined in the lines of research are developed by forming a research group within the Genetic Laboratory of the Department of Internal Medicine. In this capacity, we will provide advisory support for activities conducted by the Human Genomics Facility, particularly focusing on analytical aspects related to microarray and sequencing data. Additionally, we aim to foster research interactions and collaborations with other research groups both within and outside the Endocrinology sector, as well as within and outside of the department. These connections will extend the scope of skeletal research to other bodily systems, with the skeletal setting serving as a model of translational genomics for other fields. A key component of the Translational Skeletal Genomics program is our close collaboration with the Erasmus MC Bone Center, where the majority of efforts to integrate genetics into a clinical setting will be concentrated.
The Rotterdam Study
The Rotterdam Study, is a prospective cohort study on risk factors and determinants of chronic diseases in middle-aged and elderly persons, that started in 1990.
Generation R
UK BioBank
The UK Biobank studies genetic and environmental factors in disease development, focusing on monogenic and common disorders, polygenic risk scores, and musculoskeletal health, with significant findings in bone mineral density genetics.
Gemstone
Is a network that fosters collaboration among experts in genetics, epidemiology, bioinformatics, and clinical medicine across Europe, to enhance the translation of genomic discoveries in the musculoskeletal field, into clinical applications.
