About this study

EraSmus medIcal ceNTer skEletal fRagility (SINTER) study

Research on bone strength and the risk of fractures

At Erasmus MC, we are investigating why some people maintain strong bones—even when living with a chronic illness—while others develop weaker bones, even when otherwise healthy. This research is part of the SINTER study. With this study, we aim to better understand what determines bone strength and how to prevent fractures.

What is the purpose of the study?

We are comparing the bone strength of people with a genetically predicted low bone density to those with a genetically predicted high bone density. We are studying how genetics, lifestyle, and health influence bone strength. Our goal is to discover new ways to identify and prevent osteoporosis and bone fractures earlier.

We are also asking participants about their experiences and opinions regarding genetic research on bone health. This helps us shape future studies to better reflect patients’ preferences.

Who can participate?

The SINTER study is looking for 5,650 participants through the following outpatient clinics at Erasmus MC:

Bone Center
Diabetology
Geriatrics
Healthy Weight Center
Nephrology
Thyroid Center
Vascular Medicine
Mastocytosis Clinic

Eligibility criteria:

✔ 18 years or older
✔ Patient at one of the above clinics
✔ Willing to provide a blood sample during a routine appointment
✔ Willing to return for additional measurements if invited
✔ Not pregnant (for the second study visit)

What does participation involve?

There are two study visits:

First visit: Blood sample during a routine hospital appointment
A small blood sample will be collected during your regular visit for genetic analysis. You do not need to make an extra appointment for this.

Second visit: Additional examination at the ERGO research center
If your genetic results indicate low or high bone density, you may be invited for a follow-up visit within one year. During this visit:

An EOS Edge scan will be performed to create 2D and 3D images of your bones while you are standing upright.
The visit takes approximately 90 minutes.

The total participation period is up to 18 months.

Why is bone strength important?

Strong bones are vital for staying healthy and mobile. Weak bones increase the risk of fractures, especially with aging. Through this study, we aim to identify who is at higher risk of bone fractures and how to help people maintain strong bones longer.

Interested in participating?

Your participation will help us improve treatments and prevention strategies for bone conditions like osteoporosis.

Do you have questions or want to join the study?
Please contact our research team at:
📧 SINTER-onderzoek@erasmusmc.nl

SINTER-onderzoek@erasmusmc.nl

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