Fernando Rivadeneira

Professor Dr. M.D PhD.

I am a medical doctor and genetic epidemiologist by training, Professor of Translational Genomics with emphasis on the skeletal system. In Erasmus MC I hold appointments in the Department of Internal Medicine and the Department of Oral and Maxillofacial Surgery. My passion is my research; focusing on seeking the translation of genomic discoveries to clinical settings, holding particular emphasis on musculoskeletal health and disease outcomes. This research employs a life-course approach integrating epidemiological, imaging and genomic data within the setting of large population-based epidemiological cohorts, including the Generation R (in children) and the Rotterdam Study (in the elderly) cohorts.

My team has played pivotal roles in the identification of genetic determinants of musculoskeletal traits applying high throughput technology, (i.e., GWAS and NGS), making part of large-scale collaborations in the setting of large international GWAS consortia and making use of large scale resources, like the UK Biobank.

Favorite

“”

I am co-leading the European Commission (EC-FP7)-funded “Genetics Factors of Osteoporosis” (GEFOS) consortium and since then have been partner in multiple EC- Horizon projects. Until recently, I was chair of the “GEnomics of MusculoSkeletal traits TranslatiOnal Network” (GEMSTONE) Cost Action of the EC; and have been awarded an – European Research Council – ERC Advanced Grant for the program “LEveraging GENomic Discoveries and skeletal phenotyping to improve osteoporosis patient cARE” (LEGENDARE).

  1. Bone health index in the assessment of bone health: The Generation R Study Prijatelj, V., Grgic, O., Uitterlinden, A. G., Wolvius, E. B., Rivadeneira, F. & Medina-Gomez, C., May 2024, In: 182, 117070.

 

  1. Early-life stress and the gut microbiome: A comprehensive population-based investigation Mulder, R. H., Kraaij, R., Schuurmans, I. K., Frances-Cuesta, C., Sanz, Y., Medina-Gomez, C., Duijts, L., Rivadeneira, F., Tiemeier, H., Jaddoe, V. W. V., Felix, J. F. & Cecil, C. A. M., May 2024, In: Brain, Behavior, and Immunity. 118, p. 117-127 11 p.

 

  1. Oral microbiota of adolescents with dental caries: A systematic review Veenman, F., van Dijk, A., Arredondo, A., Medina-Gomez, C., Wolvius, E., Rivadeneira, F., Àlvarez, G., Blanc, V. & Kragt, L., Apr 2024, In: Archives of Oral Biology. 161, 105933.

 

  1. The Rotterdam Study. Design update and major findings between 2020 and 2024 Ikram, M. A., Kieboom, B. C. T., Brouwer, W. P., Brusselle, G., Chaker, L., Ghanbari, M., Goedegebure, A., Ikram, M. K., Kavousi, M., de Knegt, R. J., Luik, A. I., van Meurs, J., Pardo, L. M., Rivadeneira, F., van Rooij, F. J. A., Vernooij, M. W., Voortman, T. & Terzikhan, N., 7 Feb 2024, In: European Journal of Epidemiology. 39, 2, p. 183-206 24 p.

 

  1. Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations Ghatan, S., van Rooij, J., van Hoek, M., Boer, C. G., Felix, J. F., Kavousi, M., Jaddoe, V. W., Sijbrands, E. J. G., Medina-Gomez, C., Rivadeneira, F. & Oei, L., 10 Jan 2024, (E-pub ahead of print) In: Genome Medicine. 16, 1, 10.

 

  1. Bone mineral density and the risk of incident dementia: A meta-analysis Lary, C. W., Ghatan, S., Gerety, M., Hinton, A., Nagarajan, A., Rosen, C., Ross, R. D., Bennett, D. A., DeStefano, A. L., Ikram, M. A., Rivadeneira, F., Kiel, D. P., Seshadri, S. & Beiser, A., Jan 2024, In: Journal of the American Geriatrics Society. 72, 1, p. 194-200 7 p.

 

  1. Oral corticosteroid use and sarcopenia-related traits in older people with chronic airway disease: a population-based study Benz, E., Lahousse, L., Arinze, J. T., Wijnant, S., de Ridder, M., Rivadeneira, F., Brusselle, G. & Stricker, B. H., 1 Sept 2023, In: ERJ Open Research. 9, 5, 00492-2023.

  2. Generic Platform for the Multiplexed Targeted Electrochemical Detection of Osteoporosis-Associated Single Nucleotide Polymorphisms Using Recombinase Polymerase Solid-Phase Primer Elongation and Ferrocene-Modified Nucleoside Triphosphates Ortiz, M., Jauset-Rubio, M., Trummer, O., Foessl, I., Kodr, D., Acero, J. L., Botero, M. L., Biggs, P., Lenartowicz, D., Trajanoska, K., Rivadeneira, F., Hocek, M., Obermayer-Pietsch, B. & O’Sullivan, C. K., 23 Aug 2023, In: ACS Central Science. 9, 8, p. 1591-1602 12 p.

  3. Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review Li, R., Shokri, F., Rincon, A. L., Rivadeneira, F., Medina-Gomez, C. & Ahmadizar, F., 1 Aug 2023, In: 14, 8, 1572.

  4. Oral and craniofacial research in the Generation R study: an executive summary van Meijeren-van Lunteren, A. W., Liu, X., Veenman, F. C. H., Grgic, O., Dhamo, B., van der Tas, J. T., Prijatelj, V., Roshchupkin, G. V., Rivadeneira, F., Wolvius, E. B. & Kragt, L., Jul 2023, In: Clinical Oral Investigations. 27, 7, p. 3379-3392 14 p.

  5. Association of Bone Mineral Density and Dementia: The Rotterdam Study Xiao, T., Ghatan, S., Mooldijk, S. S., Trajanoska, K., Oei, L., Gomez, M. M., Ikram, M. K., Rivadeneira, F. & Ikram, M. A., 16 May 2023, In: 100, 20, p. e2125-e2133

  6. Association between prenatal alcohol exposure and children’s facial shape: a prospective population-based cohort study Liu, X., Kayser, M., Kushner, S. A., Tiemeier, H., Rivadeneira, F., Jaddoe, V. W. V., Niessen, W. J., Wolvius, E. B. & Roshchupkin, G. V., 1 May 2023, In: Human reproduction (Oxford, England). 38, 5, p. 961-972 12 p.

  7. Novel Genetic Determinants of Dental Maturation in Children Grgic, O., Prijatelj, V., Dudakovic, A., Vucic, S., Dhamo, B., Trajanoska, K., Monnereau, C., Zrimsek, M., Gautvik, K. M., Reppe, S., Shimizu, E., Timpson, N. J., Jaddoe, V. W. V., Jarvelin, M. R., Evans, D., Uitterlinden, A. G., Ongkosuwito, E. M., van Wijnen, A. J., Medina-Gomez, C., Rivadeneira, F., & 1 others, Mar 2023, In: Journal of Dental Research. 102, 3, p. 349-356 8 p.

  8. Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly Mekić, S., Pardo, L. M., Gunn, D. A., Jacobs, L. C., Hamer, M. A., Ikram, M. A., Vinke, E. J., Vernooij, M. W., Haarman, A. E. G., Thee, E. F., Vergroesen, J. E., Klaver, C. C. W., Croll, P. H., Goedegebure, A., Trajanoska, K., Rivadeneira, F., van Meurs, J. B. J., Arshi, B., Kavousi, M., de Roos, E. W., & 3 others, Mar 2023, In: British Journal of Dermatology. 188, 3, p. 390-395 6 p.

  9. Frailty transitions in older persons with lung function impairment: a population-based study Wijnant, S. R. A., Benz, E., Luik, A. I., Rivadeneira, F., Voortman, T., Brusselle, G. G. & Lahousse, L., 24 Feb 2023, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 78, 2, p. 349-356 8 p.

  10. High Bone Mass Disorders: New Insights From Connecting the Clinic and the Bench Bergen, D. J. M., Maurizi, A., Formosa, M. M., McDonald, G. L. K., El-Gazzar, A., Hassan, N., Brandi, M. L., Riancho, J. A., Rivadeneira, F., Ntzani, E., Duncan, E. L., Gregson, C. L., Kiel, D. P., Zillikens, M. C., Sangiorgi, L., Högler, W., Duran, I., Mäkitie, O., Van Hul, W. & Hendrickx, G., Feb 2023, In: Journal of Bone and Mineral Research. 38, 2, p. 229-247 19 p.

  11. The gut microbiome and child mental health: A population-based study Kraaij, R., Schuurmans, I. K., Radjabzadeh, D., Tiemeier, H., Dinan, T. G., Uitterlinden, A. G., Hillegers, M., Jaddoe, V. W. V., Duijts, L., Moll, H., Rivadeneira, F., Medina-Gomez, C., Jansen, P. W. & Cecil, C. A. M., Feb 2023, In: Brain, Behavior, and Immunity. 108, p. 188-196 9 p.

  12. Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants Young, K. L., Fisher, V., Deng, X., Brody, J. A., Graff, M., Lim, E., Lin, B. M., Xu, H., Amin, N., An, P., Aslibekyan, S., Fohner, A. E., Hidalgo, B., Lenzini, P., Kraaij, R., Medina-Gomez, C., Prokić, I., Rivadeneira, F., Sitlani, C., Tao, R., & 42 others, 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100163.

  13. Dietary advanced glycation end-products (dAGEs) intake and its relation to sarcopenia and frailty – The Rotterdam Study Waqas, K., Chen, J., Lu, T., van der Eerden, B. C. J., Rivadeneira, F., Uitterlinden, A. G., Voortman, T. & Zillikens, M. C., Dec 2022, In: 165, 116564.

  14. Gender and Geographic Origin as Determinants of Manuscript Publication Outcomes: JBMR® Bibliometric Analysis from 2017 to 2019 Rivadeneira, F., Loder, R. T., McGuire, A. C., Chitwood, J. R., Duffy, K., Civitelli, R., Kacena, M. A. & Westendorf, J. J., Dec 2022, In: Journal of Bone and Mineral Research. 37, 12, p. 2420-2434 15 p.

  15. Plasma circulating microRNAs associated with obesity, body fat distribution, and fat mass: the Rotterdam Study Abozaid, Y. J., Zhang, X., Mens, M. M. J., Ahmadizar, F., Limpens, M., Ikram, M. A., Rivadeneira, F., Voortman, T., Kavousi, M. & Ghanbari, M., Dec 2022, In: International Journal of Obesity. 46, 12, p. 2137-2144 8 p.

  16. Skin Autofluorescence, a Noninvasive Biomarker of Advanced Glycation End-products, Is Associated With Frailty: The Rotterdam Study Waqas, K., Chen, J., Rivadeneira, F., Uitterlinden, A. G., Voortman, T. & Zillikens, M. C., 1 Oct 2022, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 77, 10, p. 2032-2039 8 p.

  17. The genetic overlap between osteoporosis and craniosynostosis Kague, E., Medina-Gomez, C., Boyadjiev, S. A. & Rivadeneira, F., 26 Sept 2022, In: Frontiers in Endocrinology. 13, 1020821.

  18. Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study Benz, E., Wijnant, S. R. A., Trajanoska, K., Arinze, J. T., de Roos, E. W., de Ridder, M., Williams, R., van Rooij, F., Verhamme, K. M. C., Ikram, M. A., Stricker, B. H., Rivadeneira, F., Lahousse, L. & Brusselle, G. G., Aug 2022, In: ERJ Open Research. 8, 1, 00628-2021.

  19. Reply to ‘The emerging evidence for non-skeletal health benefits of vitamin D supplementation in adults’ Bouillon, R., Manousaki, D., Rosen, C., Trajanoska, K., Rivadeneira, F. & Richards, J. B., May 2022, In: Nature Reviews Endocrinology. 18, 324, p. 324 1 p.

  20. Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults Pronk, A. C., Seppala, L. J., Trajanoska, K., Stringa, N., van de Loo, B., de Groot, L. C. P. G. M., van Schoor, N. M., Koskeridis, F., Markozannes, G., Ntzani, E., Uitterlinden, A. G., Rivadeneira, F., Stricker, B. H. & van der Velde, N., 14 Apr 2022, In: PLoS ONE. 17, 4 April, e0266590.

  21. Bone fragility in diabetes: novel concepts and clinical implications Hofbauer, L. C., Busse, B., Eastell, R., Ferrari, S., Frost, M., Müller, R., Burden, A. M., Rivadeneira, F., Napoli, N. & Rauner, M., Mar 2022, In: The Lancet Diabetes and Endocrinology. 10, 3, p. 207-220 14 p.

  22. Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Sarcopenia Waqas, K., Chen, J., Trajanoska, K., Ikram, M. A., Uitterlinden, A. G., Rivadeneira, F. & Zillikens, M. C., 1 Feb 2022, In: The Journal of clinical endocrinology and metabolism. 107, 2, p. e793-e803

  23. The health effects of vitamin D supplementation: evidence from human studies Bouillon, R., Manousaki, D., Rosen, C., Trajanoska, K., Rivadeneira, F. & Richards, J. B., Feb 2022, In: Nature Reviews Endocrinology. 18, 2, p. 96-110 15 p.

  24. Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques Rauner, M., Foessl, I., Formosa, M. M., Kague, E., Prijatelj, V., Lopez, N. A., Banerjee, B., Bergen, D., Busse, B., Calado, Â., Douni, E., Gabet, Y., Giralt, N. G., Grinberg, D., Lovsin, N. M., Solan, X. N., Ostanek, B., Pavlos, N. J., Rivadeneira, F., Soldatovic, I., & 8 others, 30 Nov 2021, In: Frontiers in Endocrinology. 12, 731217.

  25. A comparison of genotyping arrays Verlouw, J. A. M., Clemens, E., de Vries, J. H., Zolk, O., Verkerk, A. J. M. H., am Zehnhoff-Dinnesen, A., Medina-Gomez, C., Lanvers-Kaminsky, C., Rivadeneira, F., Langer, T., van Meurs, J. B. J., van den Heuvel-Eibrink, M. M., Uitterlinden, A. G. & Broer, L., Nov 2021, In: European Journal of Human Genetics. 29, 11, p. 1611-1624 14 p.

  26. The “GEnomics of Musculo Skeletal Traits TranslatiOnal NEtwork”: Origins, Rationale, Organization, and Prospects Koromani, F., Alonso, N., Alves, I., Brandi, M. L., Foessl, I., Formosa, M. M., Morgenstern, M. F., Karasik, D., Kolev, M., Makitie, O., Ntzani, E., Pietsch, B. O., Ohlsson, C., Rauner, M., Soe, K., Soldatovic, I., Teti, A., Valjevac, A. & Rivadeneira, F., 16 Aug 2021, In: Frontiers in Endocrinology. 12, 709815.

2011

The Alliance for Better Bone Health Iain T Boyle Award – European Calcified Tissue Society

2015

World’s Most Influential Scientific Minds – Thomson Reuters Highly Cited Researcher

Fuller Albright Award – American Society for Bone and Mineral Research

2023
Medicine in Netherlands Leader Award – Research.com

Genetics in Netherlands Leader Award – Research.com

2022

Genetics and Molecular Biology in Netherlands Leader Award – Research.com

European Research Council Advance Grand(ERC, LEGENDARE,101021500)

Bone Fragility In Diabetes in Europe – towards a persona Lised medIcine approach (FIDELIO-ITN);

GEnomics of MusculoSkeletal traits TranslatiOnal Network – GEMSTONE(CA18139 Cost Action);

From genetic discoveries to clinical applications – comprehensive phenotyping of the musculoskeletal system (ZonMW VIDI-016-136-367);

 Pleiotropy and Phenomics of Musculoskeletal Aging – (NIH-NIAAMS);

Genetic Factors of Osteoporosis – (GEFOS) (EC-FP7-HEALTH- F2-2008-201865);