Katerina Trajanoska
I have a medical background and substantial experience in genetics and translational research. I was trained as a nurse and as a medical doctor in Macedonia and specialized in Genetic Epidemiology at the Erasmus Medical Center. My PhD was focused on musculoskeletal genomics identifying causal risk factors for musculoskeletal diseases with an emphasis on utilizing polygenic risk scores to predict disease susceptibility and employing Mendelian Randomization for causal inference analysis.
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I have made several important contributions to the understanding of musculoskeletal health, applying both epidemiological and genomic technologies resulting in more than 50 original research papers, reviews and book chapters. My research projects had a very collaborative and international character where I led and contributed to numerous research lines within international consortia, such as the GEnetic Factors for OSteoporosis Consortium (GEFOS) and the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE).
After my PhD, I moved to Canada for three years to do postdoctoral work at the Genome Medicine Canada Excellence Research Chair (CERC) program in McGill University, working on sequencing efforts for cardiovascular diseases prevention programs. During my postdoctoral training I also gain interest in the interplay between monogenic and polygenic variations in complex diseases to identify novel pathways and further strengthen the drug discovery and development pipeline.
Currently I am working as assistant professor at the Translation Skeletal Genomics group with an end goal to help answer translational questions regarding the utility of using genomics data and performing genomics-assisted medical decision-making. I am also actively involved as a teaching assistant and lecturer at The Netherlands Institute for Health Sciences (NIHES) programme.
1. From target discovery to clinical drug development with human genetics. Trajanoska K, Bhérer C, Taliun D, Zhou S, Richards JB, Mooser V. Nature. 2023 Aug;620(7975):737-745 Epub 2023 Aug 23. PMID: 37612393 Review.
2. Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population Kocevska, D., Trajanoska, K., Mulder, R. H., Koopman-Verhoeff, M. E., Luik, A. I., Tiemeier, H. & van Someren, E. J. W., May 2024, In: Journal of Child Psychology and Psychiatry and Allied Disciplines. 65, 5, p. 710-719 10 p.
3. A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome. Bhérer C, Eveleigh R, Trajanoska K, St-Cyr J, Paccard A, Nadukkalam Ravindran P, Caron E, Bader Asbah N, McClelland P, Wei C, Baumgartner I, Schindewolf M, Döring Y, Perley D, Lefebvre F, Lepage P, Bourgey M, Bourque G, Ragoussis J, Mooser V, Taliun D. NPJ Genom Med. 2024 Feb 7;9(1):8.
4. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J., Stinson, S. E., Trajanoska, K., Wang, C. A., Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., Bilbao, J. R., & 68 others, Nov 2023, In: Nature Genetics. 55, 11, p. 1807-1819 13 p.
5. Generic Platform for the Multiplexed Targeted Electrochemical Detection of Osteoporosis-Associated Single Nucleotide Polymorphisms Using Recombinase Polymerase Solid-Phase Primer Elongation and Ferrocene-Modified Nucleoside Triphosphates Ortiz, M., Jauset-Rubio, M., Trummer, O., Foessl, I., Kodr, D., Acero, J. L., Botero, M. L., Biggs, P., Lenartowicz, D., Trajanoska, K., Rivadeneira, F., Hocek, M., Obermayer-Pietsch, B. & O’Sullivan, C. K., 23 Aug 2023, In: ACS Central Science. 9, 8, p. 1591-1602 12 p.
6. Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis Medina-Gomez, C., Mullin, B. H., Chesi, A., Prijatelj, V., Kemp, J. P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T. E., Schraut, K. E., Li-Gao, R., Ahluwalia, T. S., Zillikens, M. C., Zhu, K., Mook-Kanamori, D. O., Evans, D. S., Nethander, M., Knol, M. J., Thorleifsson, G., & 38 others, 4 Jul 2023, In: Communications Biology. 6, 1, 691.
7. Association of Bone Mineral Density and Dementia: The Rotterdam Study Xiao, T., Ghatan, S., Mooldijk, S. S., Trajanoska, K., Oei, L., Gomez, M. M., Ikram, M. K., Rivadeneira, F. & Ikram, M. A., 16 May 2023, In: 100, 20, p. e2125-e2133
8. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease Young, W. J., Haessler, J., Benjamins, J. W., Repetto, L., Yao, J., Isaacs, A., Harper, A. R., Ramirez, J., Garnier, S., van Duijvenboden, S., Baldassari, A. R., Concas, M. P., Duong, T. V., Foco, L., Isaksen, J. L., Mei, H., Noordam, R., Nursyifa, C., Richmond, A., Santolalla, M. L., & 74 others, 14 Mar 2023, In: Nature Communications. 14, 1, 1411.
9. Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly Mekić, S., Pardo, L. M., Gunn, D. A., Jacobs, L. C., Hamer, M. A., Ikram, M. A., Vinke, E. J., Vernooij, M. W., Haarman, A. E. G., Thee, E. F., Vergroesen, J. E., Klaver, C. C. W., Croll, P. H., Goedegebure, A., Trajanoska, K., Rivadeneira, F., van Meurs, J. B. J., Arshi, B., Kavousi, M., de Roos, E. W., & 3 others, Mar 2023, In: British Journal of Dermatology. 188, 3, p. 390-395 6 p.
10. Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study Benz, E., Wijnant, S. R. A., Trajanoska, K., Arinze, J. T., de Roos, E. W., de Ridder, M., Williams, R., van Rooij, F., Verhamme, K. M. C., Ikram, M. A., Stricker, B. H., Rivadeneira, F., Lahousse, L. & Brusselle, G. G., Aug 2022, In: ERJ Open Research. 8, 1, 00628-2021.
11. Novel Genetic Determinants of Dental Maturation in Children. Grgic O, Prijatelj V, Dudakovic A, Vucic S, Dhamo B, Trajanoska K, Monnereau C, Zrimsek M, Gautvik KM, Reppe S, Shimizu E, Haworth S, Timpson NJ, Jaddoe VWV, Jarvelin MR, Evans D, Uitterlinden AG, Ongkosuwito EM, van Wijnen AJ, Medina-Gomez C, Rivadeneira F, Wolvius EB. J Dent Res. 2023 Mar;102(3):349-356.
12. Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults. Pronk, A. C., Seppala, L. J., Trajanoska, K., Stringa, N., van de Loo, B., de Groot, L. C. P. G. M., van Schoor, N. M., Koskeridis, F., Markozannes, G., Ntzani, E., Uitterlinden, A. G., Rivadeneira, F., Stricker, B. H. & van der Velde, N., 14 Apr 2022, In: PLoS ONE. 17, 4 April, e0266590.
13. Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Sarcopenia. Waqas, K., Chen, J., Trajanoska, K., Ikram, M. A., Uitterlinden, A. G., Rivadeneira, F. & Zillikens, M. C., 1 Feb 2022, In: The Journal of clinical endocrinology and metabolism. 107, 2, p. e793-e803.
14. Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study. Benz E, Wijnant SRA, Trajanoska K, Arinze JT, de Roos EW, de Ridder M, Williams R, van Rooij F, Verhamme KMC, Ikram MA, Stricker BH, Rivadeneira F, Lahousse L, Brusselle GG. ERJ Open Res. 2022 Jan 10;8(1):00628-2021. eCollection 2022 Jan.
15. The health effects of vitamin D supplementation: evidence from human studies Bouillon, R., Manousaki, D., Rosen, C., Trajanoska, K., Rivadeneira, F. & Richards, J. B., Feb 2022, In: Nature Reviews Endocrinology. 18, 2, p. 96-110 15 p.
16. Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”). Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., Christou, M., Douni, E., Fiedler, I. A. K., Fonseca, J. E., Hassler, E., Högler, W., Kague, E., Karasik, D., Khashayar, P., Langdahl, B. L., Leitch, V. D., Lopes, P., Markozannes, G., McGuigan, F. E. A., & 14 others, 1 Dec 2021, In: Frontiers in Endocrinology. 12, 720728.
17. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density Liu, C. T., Karasik, D., Xu, H., Zhou, Y., Broe, K., Cupples, L. A., Cpgm De Groot, L., Ham, A., Hannan, M. T., Hsu, Y. H., Jacques, P., Mclean, R. R., Paul, L., Selhub, J., Trajanoska, K., van der Velde, N., Van Schoor, N. & Kiel, D. P., 2 Aug 2021, In: American Journal of Clinical Nutrition. 114, 2, p. 578-587 10 p.
18. Pharmacogenomic Effects of β-Blocker Use on Femoral Neck Bone Mineral Density Nevola, K. T., Nagarajan, A., Hinton, A. C., Trajanoska, K., Formosa, M. M., Xuereb-Anastasi, A., Van Der Velde, N., Stricker, B. H., Rivadeneira, F., Fuggle, N. R., Westbury, L. D., Dennison, E. M., Cooper, C., Kiel, D. P., Motyl, K. J. & Lary, C. W., 1 Aug 2021, In: Journal of the Endocrine Society. 5, 8, bvab092.
19. Associations between Prenatal, Perinatal, and Early Childhood Vitamin D Status and Risk of Dental Caries at 6 Years Navarro, C. L. A., Grgic, O., Trajanoska, K., Van Der Tas, J. T., Rivadeneira, F., Wolvius, E. B., Voortman, T. & Kragt, L., 1 Jul 2021, In: Journal of Nutrition. 151, 7, p. 1993-2000 8 p.
20. Mendelian randomization study on vitamin D levels and osteoarthritis risk: A concise report Bergink, A. P., Trajanoska, K., Uitterlinden, A. G. & Van Meurs, J. B. J., 1 Jul 2021, In: Rheumatology (United Kingdom). 60, 7, p. 3409-3412 4 p.
21. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women Jones, G., Trajanoska, K., Santanasto, AJ., Stringa, N., Kuo, CL., Atkins, JL., Lewis, JR., Duong, TV., Hong, S., Biggs, ML., Luan, J., Sarnowski, C., Lunetta, KL., Tanaka, T., Wojczynski, MK., Cvejkus, R., Nethander, M., Ghasemi, S., Yang, J., Zillikens, M. C., & 46 others, 28 Jan 2021, In: Nature Communications. 12, 1, 654.
22. The interplay of bone and muscle in health and disease Trajanoska, K., 7 Oct 2020, Erasmus Universiteit Rotterdam (EUR).
23. Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health? Oliai Araghi, S., Jong, J., Trajanoska, K., Koromani, F., Rivadeneira, F., Zillikens, M. C., Schoor, NM., de Groot, LCPCM., Ikram, A., Uitterlinden, A., Stricker, B. & van der Velde, N., 2020, In: Calcified Tissue International. 106, p. 104-114 11 p.
24. Genetic basis of falling risk susceptibility in the UK Biobank Study Trajanoska, K., Seppala, LJ., Medina Gomez, M., Hsu, YH., Zhou, SR., Schoor, NM., de Groot, LCPCM., Karasik, D., Richards, JB., Kiel, DP., Uitterlinden, A., Perry, J., van de Velde, N., Day, F. & Rivadeneira, F., 2020, In: Communications Biology. 3, 1, 543.
25. Genomic Medicine: Lessons Learned From Monogenic and Complex Bone Disorders Trajanoska, K. & Rivadeneira, F., 2020, In: Frontiers in Endocrinology (Lausanne) (online). 11, 556610.
26. Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study Magnus, MC., Guyatt, AL., Lawn, RB., Wyss, AB., Trajanoska, K., Kupers, LK., Rivadeneira, F., Tobin, MD., London, SJ., Lawlor, DA., Millard, LAC. & Fraser, A., 2020, In: BMC Medicine. 18, 1, 71.
27. Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-Products, Is Associated With Prevalent Vertebral and Major Osteoporotic Fractures: The Rotterdam Study Waqas, K., Chen, J., Koromani, F., Trajanoska, K., van der Eerden, B., Uitterlinden, A., Rivadeneira, F. & Zillikens, M. C., 2020, In: Journal of Bone and Mineral Research. 35, 10, p. 1904-1913 10 p.
28. Total Dietary Antioxidant Capacity and Longitudinal Trajectories of Body Composition Schaft, N., Trajanoska, K., Rivadeneira, F., Ikram, A., Schoufour, J. & Voortman, T., 2020, In: 9, 8, 728.
2017
ECTS Travel grant – The European Calcified Tissue Society Congress
2018
ASBMR Travel grant – American Society of Bone Mineral Research Congress
2019
ECTS Travel grant – The European Calcified Tissue Society Congress