Xinpeng He

PhD Researcher

My PhD topic is Exploring the effects of exposome factors on musculoskeletal traits. Osteoporosis is considered as a systemic multifactorial disease caused by a combination of genetic, environmental, and lifestyle factors. “Exposome” was first defined by Wild as the totality of human environmental (meaning all non-genetic) exposures from conception onwards, complementing the genome.

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“My favorite food is Cantonese cuisine. And l love playing basketball “

With the development of tools and technologies, the concept of measuring more complete exposure data became challenging. The project is mainly focus on investigating the relationship between exposome (including both social and environmental exposomes) and bone health. Here are the sub-projects:

Alcohol consumption and bone mineral density in the Rotterdam Study: a Mendelian randomization analysis
Alcohol exposure during pregnancy and bone mineral density in childhood in the Generation R study
Smoking cessation, BMD, and trabecular bone score (TBS) in the Rotterdam Study
Maternal socioeconomic status and social capital and bone health in Generation R

Projects
Publications

High Curie Temperature Achieved in the Ferromagnetic Mn_xGe_1-x/Si Quantum Dots Grown by Ion Beam Co-Sputtering.
Duan X, Ye S, Yang J, Li C, Lu C, He X, Zhang L, Wang R, Qiu F, Yang J, Cui H, Wang C.Nanomaterials (Basel). 2022 Feb 21;12(4):716. doi: 10.3390/nano12040716.PMID: 35215045 Free PMC article.
Heavy metal exposure, oxidative stress and semen quality: Exploring associations and mediation effects in reproductive-aged men. He Y, Zou L, Luo W, Yi Z, Yang P, Yu S, Liu N, Ji J, Guo Y, Liu P, He X, Lv Z, Huang S.Chemosphere. 2020 Apr;244:125498. doi: 10.1016/j.chemosphere.2019.125498. Epub 2019 Nov 27.PMID: 31812049

The association between metal exposure and semen quality in Chinese males: The mediating effect of androgens. Liu P, Yuan G, Zhou Q, Liu Y, He X, Zhang H, Guo Y, Wen Y, Huang S, Ke Y, Chen J.Environ Pollut. 2020 Sep;264:113975. doi: 10.1016/j.envpol.2020.113975. Epub 2020 Jan 22.PMID: 32559873

Blood miR-1275 is associated with risk of ischemic stroke and inhibits macrophage foam cell formation by targeting ApoC2 gene. Li L, Xu W, Fu X, Huang Y, Wen Y, Xu Q, He X, Wang K, Huang S, Lv Z.Gene. 2020 Mar 20;731:144364. doi: 10.1016/j.gene.2020.144364.

Xinpeng He

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