Xinpeng He
My PhD topic is Exploring the effects of exposome factors on musculoskeletal traits. Osteoporosis is considered as a systemic multifactorial disease caused by a combination of genetic, environmental, and lifestyle factors. “Exposome” was first defined by Wild as the totality of human environmental (meaning all non-genetic) exposures from conception onwards, complementing the genome.
Favorite
“My favorite food is Cantonese cuisine. And l love playing basketball “
With the development of tools and technologies, the concept of measuring more complete exposure data became challenging. The project is mainly focus on investigating the relationship between exposome (including both social and environmental exposomes) and bone health. Here are the sub-projects:
- Alcohol consumption and bone mineral density in the Rotterdam Study: a Mendelian randomization analysis
- Alcohol exposure during pregnancy and bone mineral density in childhood in the Generation R study
- Smoking cessation, BMD, and trabecular bone score (TBS) in the Rotterdam Study
- Maternal socioeconomic status and social capital and bone health in Generation R
1. Liu, P., Yuan, G., Zhou, Q., Liu, Y., He, X., Zhang, H., … & Chen, J. (2020). The association between metal exposure and semen quality in Chinese males: The mediating effect of androgens. Environmental pollution, 264, 113975.
2. Li, L., Xu, W., Fu, X., Huang, Y., Wen, Y., Xu, Q., He, X., … & Lv, Z. (2020). Blood miR-1275 is associated with risk of ischemic stroke and inhibits macrophage foam cell formation by targeting ApoC2 gene. Gene, 731, 144364.
3. Sun, M., He, X., Mao, L., Ma, T., Deng, J., Gao, L., … & Chen, G. (2022). Correlation analyses between age and indices in routine blood laboratory tests suggest potential aging biomarkers. Annals of Blood, 7
4. He, Y., Zou, L., Luo, W., Yi, Z., Yang, P., Yu, S., Liu, N., Ji, J., Guo, Y., Liu, P., He, X.,… & Huang, S. (2020). Heavy metal exposure, oxidative stress and semen quality: exploring associations and mediation effects in reproductive-aged men. Chemosphere, 244, 125498.