Deep (musculo) skeletal phenotyping

Our research focuses on advancing the understanding of musculoskeletal health through deep phenotyping, integrating various measures that assess bone strength, muscle function, and overall body composition. By exploring the intricate connections between genetics, environment, and lifestyle factors, we aim to develop targeted interventions and better diagnostic tools for musculoskeletal disorders.

Bone Mineral Density (BMD)
BMD measures the mineral content of bone tissue, crucial for assessing bone strength and diagnosing conditions like osteoporosis and osteopenia. Low BMD indicates weaker bones and an increased risk of fractures, particularly in the hip, spine, and wrist. Our research investigates the genetic and environmental factors influencing BMD, aiming to develop new treatments and tools for fracture risk prediction.

Body Composition
Body composition refers to the ratio of lean mass (muscle, bone, organs) to fat mass in the body. Imbalances—such as excess fat or low muscle mass—are linked to an increased risk of metabolic disorders, cardiovascular diseases, and musculoskeletal problems. We study the mechanisms behind body composition changes, focusing on interventions that promote a healthy balance and exploring how these changes relate to disease outcomes.

Trabecular Bone Score (TBS)
TBS evaluates the quality of trabecular bone microarchitecture and offers an independent assessment of fracture risk, even in individuals with normal or near-normal BMD. Research is focused on validating TBS as a tool for fracture risk prediction and understanding the factors that affect bone microarchitecture.

Bone Material Strength Index (BMSi)
BMSi measures the mechanical strength and quality of bone tissue, providing insights into fracture risk that go beyond BMD and microarchitecture. Low BMSi indicates compromised bone material properties, increasing fracture risk even in those with normal BMD. Our research aims to explore the relationship between BMSi and fracture risk.

Sagittal Alignment
The curvature and alignment of the spine in the sagittal plane, known as sagittal alignment, are key to understanding spinal health. Abnormal alignment, such as kyphosis or lordosis, can lead to back pain and functional impairment. We explore the biomechanics of spinal alignment and its impact on musculoskeletal diseases and overall health.

Cobb’s Angle
Cobb’s angle is used to assess spinal curvature, particularly for diagnosing and monitoring scoliosis. Our research focuses on understanding the underlying causes of spinal deformities and the progression of scoliosis over time.

Muscle Strength
Muscle strength, a measure of force produced during voluntary muscle contractions, is crucial for overall mobility and health. Weakness or imbalances can lead to functional limitations and increased fall risk. Our research delves into the mechanisms of muscle strength and fatigue, examining its impact on musculoskeletal disease and general health.

Jumping Force
Jumping force is an indicator of lower limb strength, neuromuscular control, and coordination. It is critical for assessing athletic performance, injury prevention, and rehabilitation. Our research seeks to understand the biomechanics of jumping force and its implications for fracture risk and musculoskeletal health.

By integrating these various measures, our research strives to enhance musculoskeletal health, improve diagnosis and treatment of musculoskeletal disorders, and contribute to a healthier future for individuals of all ages.